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JWH 018 is a mildly selective agonist of the peripheral cannabinoid (CB2) receptor,
derived from the aminoalkylindole WIN 55,212-2. The Ki values for binding central
cannabinoid (CB1) and CB2 receptors are 9.0 and 2.94 nM, respectively, for a CB1:CB2
ratio of 3.06.1 Its effects on suppression of spontaneous activity, maximum possible
antinociceptive effect in the tail-flick assay, and rectal temperature are comparable to
those of WIN 55,212-2 when tested in rats.
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